绿茶EGCG防癌作用的分子靶点

doi:10.13305/j.cnki.jts.2010.06.002

茶叶科学 ›› 2010, Vol. 30 ›› Issue (6): 414-422.doi: 10.13305/j.cnki.jts.2010.06.002

绿茶EGCG防癌作用的分子靶点

顾成波^1,2,5, 袁肖寒^3,4, 付玉杰^1,2, 祖元刚^1,2,*, 赵恩泽^1,2, 李旺^1,2, 王秋雪^1,2

1. 东北林业大学森林植物生态学教育部重点实验室,黑龙江哈尔滨 150040;
2. 东北林业大学林业生物制剂教育部工程研究中心,黑龙江哈尔滨 150040;
3. 东北林业大学林学院,黑龙江哈尔滨 150040;
4. 东北农业大学生命科学与生物技术研究中心,黑龙江哈尔滨 150030;
5. 浙江海正药业股份有限公司,浙江台州 318000

收稿日期:2010-01-06 修回日期:2010-03-11 发布日期:2019-09-11
通讯作者: zygorl@yahoo.com.cn
作者简介:顾成波（1975— ）,男,黑龙江哈尔滨人,讲师,主要从事药用植物活性成分提取分离及其药理作用研究。
基金资助:
国家科技支撑计划资助项目(2006BAD18B0401),中央高校基本科研业务费专项资金（DL09BA20）,东北林业大学青年科研基金（07030）

Molecular Targets for Cancer Chemoprevention by (-)-Epigallocatechin Gallate of Green Tea

GU Cheng-bo^1,2,5, YUAN Xiao-han^3,4, FU Yu-jie^1,2, ZU Yuan-gang^1,2,*, ZHAO En-ze^1,2, LI Wang^1,2, WANG Qiu-xue^1,2

1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China;
2. Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China;
3. College of Forestry, Northeast Forestry University, Harbin 150040, China;
4. Life Science and Biotechnique Research Center, Northeast Agricultural University, Harbin 150030, China;
5. Zhejiang Hisun Pharmaceutical Co. Ltd, Taizhou 318000, China

Received:2010-01-06 Revised:2010-03-11 Published:2019-09-11

摘要/Abstract

摘要： 表没食子儿茶素没食子酸酯（EGCG）是绿茶中含量最高、活性最强的多酚类成分。近年来绿茶EGCG癌症预防作用的分子靶点一直备受关注。本文对已报道的EGCG癌症预防作用机制及其可能的作用靶点进行了综述,讨论了将EGCG开发为癌症化学预防剂应采取的策略,以期为设计预防癌症的新方案提供借鉴。

关键词: EGCG, 癌症化学预防, 分子机制, 分子靶点

Abstract: (-)-Epigallocatechin gallate (EGCG) is the most active and major polyphenolic compound in green tea. The molecular mechanisms and targets on the action of EGCG have been extensively investigated. This paper reviewed some of the reported mechanisms and possible targets for the action of EGCG, and strategies for cancer chemoprevention by EGCG in clinical trials were discussed. It provides a new inspiration for cancer chemoprevention.

Key words: EGCG, cancer chemoprevention, molecular mechanisms, molecular targets

中图分类号:

TS272
R730.1

顾成波, 袁肖寒, 付玉杰, 祖元刚, 赵恩泽, 李旺, 王秋雪. 绿茶EGCG防癌作用的分子靶点[J]. 茶叶科学, 2010, 30(6): 414-422. doi: 10.13305/j.cnki.jts.2010.06.002.

GU Cheng-bo, YUAN Xiao-han, FU Yu-jie, ZU Yuan-gang, ZHAO En-ze, LI Wang, WANG Qiu-xue. Molecular Targets for Cancer Chemoprevention by (-)-Epigallocatechin Gallate of Green Tea[J]. Journal of Tea Science, 2010, 30(6): 414-422. doi: 10.13305/j.cnki.jts.2010.06.002.

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绿茶EGCG防癌作用的分子靶点

Molecular Targets for Cancer Chemoprevention by (-)-Epigallocatechin Gallate of Green Tea

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