茶叶主要特征性化合物抗心血管炎症研究进展

doi:10.13305/j.cnki.jts.20191202.004

摘要/Abstract

摘要： 慢性炎症是诱发动脉粥样硬化、高血压、心肌梗死等心血管疾病的重要原因之一。炎症因子如IL-6、TNF-α、IL-1β等均能导致心肌肥大、心肌纤维化和血管平滑肌细胞异常增殖。茶叶中富含的多种特征性化合物如茶多酚、茶氨酸、茶黄素、咖啡碱等,它们通过抑制重要炎症介质的产生和调控NF-κB、MAPK、Tolls样受体等信号通路,抑制心血管炎症的发生及发展,对心血管疾病具有预防和治疗作用。本文综述了近几年茶叶中的茶多酚、茶氨酸、茶黄素等特征成分通过抑制心血管炎症预防心血管疾病的作用及其机制的研究进展。

关键词: 心血管炎症, 茶多酚, 信号通路, 特征性化合物

Abstract: Chronic inflammation is one of the important causes of cardiovascular diseases such as atherosclerosis, hypertension and myocardial infarction. Inflammatory factors such as IL-6, TNF-α and IL-1β can induce many cardiovascular diseases, including myocardial hypertrophy, myocardial fibrosis and abnormal proliferation of vascular smooth muscle cells. Tea is rich in characteristic compounds. These compounds play preventive and therapeutic roles for cardiovascular diseases by inhibiting proinflammatory cytokines production, and regulating the signal pathways such as NF-κB, MAPK and Tolls-like receptors. In this review, we summarized the recent advance of the main characteristic compounds in tea on preventing inflammation related cardiovascular diseases.

Key words: cardiovascular inflammation, tea polyphenols, signaling pathways, characteristic compounds

中图分类号:

姚敏, 李大祥, 谢忠稳. 茶叶主要特征性化合物抗心血管炎症研究进展[J]. 茶叶科学, 2020, 40(1): 1-14. doi: 10.13305/j.cnki.jts.20191202.004.

YAO Min, LI Daxiang, XIE Zhongwen. Recent Advance on Anti-cardiovascular Inflammation of Major Characteristic Compounds in Tea[J]. Journal of Tea Science, 2020, 40(1): 1-14. doi: 10.13305/j.cnki.jts.20191202.004.

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