饮用金花香橼茶3个月对小样本高脂血症人群糖脂代谢的改善效果研究

doi:10.13305/j.cnki.jts.2022.04.010

茶叶科学 ›› 2022, Vol. 42 ›› Issue (4): 561-576.doi: 10.13305/j.cnki.jts.2022.04.010

饮用金花香橼茶3个月对小样本高脂血症人群糖脂代谢的改善效果研究

孙颖^1,3,4, 陈鑫^1,3,4, 杨华², 应剑^1,3,4, 邵丹青^1,3,4,*, 吕晓华^2,*, 肖杰^1,3,4, 陈志雄⁵, 李颂⁶, 覃俊杰⁷, 郑斌⁵, 高建设⁵

1.中粮营养健康研究院有限公司,北京 102209;
2.四川大学华西公共卫生学院/四川大学华西第四医院,四川成都 610041;
3.营养健康与食品安全北京市重点实验室,北京 102209;
4.老年营养食品研究北京市工程实验室,北京 102209;
5.厦门茶叶进出口有限公司,福建厦门 361013;
6.中茶科技（北京）有限公司,北京 102209;
7.深圳谱元科技有限公司,广东深圳 518000

收稿日期:2022-02-08 修回日期:2022-03-17 出版日期:2022-08-15 发布日期:2022-08-23
通讯作者: *shaodanqing@cofco.com;luxiaohua@scu.edu.cn
作者简介:孙颖,女,工程师,主要从事食物与营养方向研究。
基金资助:
中粮集团重大项目-2017、云南科技专项-2021

Clinical Trial on the Effect of Drinking Jinhua Xiangyuan Tea for 3 Months on the Improvement of Glucose and Lipid Metabolism in A Small Sample Hyperlipidemia Population

SUN Ying^1,3,4, CHEN Xin^1,3,4, YANG Hua², YING Jian^1,3,4, SHAO Danqing^1,3,4,*, LÜ Xiaohua^2,*, XIAO Jie^1,3,4, CHEN Zhixiong⁵, LI Song⁶, QIN Junjie⁷, ZHENG Bin⁵, GAO Jianshe⁵

1. Nutrition and Health Research Institute, COFCO Ltd., Beijing 102209, China;
2. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China;
3. Beijing Key Laboratory of Nutrition & Health and Food Safety, Beijing 102209, China;
4. Beijing Engineering Laboratory for Geriatric Nutrition Food Research, Beijing 102209, China;
5. Xiamen Tea Import and Export Co., Ltd., Xiamen 361013, China;
6. China Tea Technology (Beijing) Co., Ltd., Beijing 102209, China;
7. Shenzhen Puyuan Technology Co., Ltd., Shenzhen 518000, China

Received:2022-02-08 Revised:2022-03-17 Online:2022-08-15 Published:2022-08-23

摘要/Abstract

摘要： 探讨一款用黑茶工艺、经冠突散囊菌发花的乌龙茶——金花香橼茶饮用3个月对小样本高脂血症人群糖脂代谢的临床改善效果。招募38名志愿者,试饮金花香橼茶3个月,通过检测和对比试饮前后的体成分（体重、体脂百分比等）、血液生化指标（空腹血糖、血尿酸、血脂四项）、肝脏超声、肠道菌群等,探讨金花香橼茶的健康功效。结果表明,试饮金花香橼茶3个月后,志愿者体重、体质指数、体脂百分比、内脏脂肪等级、血清总胆固醇、低密度脂蛋白胆固醇、空腹血糖显著降低（P<0.05）,脂肪肝严重程度减轻,肠道菌群均匀性和多样性增加,考拉杆菌属（Phascolarctobacterium）、瘤胃球菌属（Ruminococcus）、嗜血杆菌属（Haemophilus）、韦荣球菌属（Veillonella）等丰度升高,戴阿利斯特杆菌属（Dialister）、丁酸蓖麻单胞菌属（Butyricimonas）丰度降低。提示金花香橼茶具有辅助降血糖、降血脂、改善非酒精性脂肪肝的作用,可能通过增加产短链脂肪酸菌属的丰度,增加短链脂肪酸,改善胰岛素抵抗,进而改善糖脂代谢。本研究所得结果仍需更加严谨的长期试验进一步加以确证。

关键词: 金花香橼茶, 糖脂代谢, 肠道菌群, 短链脂肪酸

Abstract: This study is aimed at investigating the clinical effect of drinking Jinhua Xiangyuan tea for 3 months on the glucose and lipid metabolism in a small sample patients with hyperlipidemia (with/without non-alcoholic fatty liver). Jinhua Xiangyuan tea was produced by the new process using Eurotium cristatum. In this study, before-and-after control design was used. The body composition (body weight, BMI, waist hip ratio, percentage of body fat, visceral fat grade), blood biochemical indicators (fasting blood glucose, uric acid, blood lipid), fatty liver, and gut microbiota were examined before and after the test. After drinking Jinhua Xiangyuan tea for 3 months, the body weight, BMI, percentage of body fat, visceral fat grade, serum total cholesterol, low-density lipoprotein cholesterol, and fasting blood glucose of 38 volunteers were significantly reduced (P<0.05). Fatty liver was less severe. Gut microbiota’s diversity and richness were increased. The relative abundance of Phascolarctobacterium, Ruminococcus, Haemophilus and Veillonella were increased, and Dialister and Butyricimonas were decreased. Jinhua Xiangyuan tea could increase the relative abundance of short-chain fatty acid-producing bacteria, increasing short-chain fatty acids, and improving insulin resistance, then improving glucose and lipid metabolism. The results of this study still need to be further confirmed by more rigorous long-term experimental observation.

Key words: Jinhua Xiangyuan tea, glucose and lipid metabolism, gut microbiota, short-chain fatty acids

中图分类号:

孙颖, 陈鑫, 杨华, 应剑, 邵丹青, 吕晓华, 肖杰, 陈志雄, 李颂, 覃俊杰, 郑斌, 高建设. 饮用金花香橼茶3个月对小样本高脂血症人群糖脂代谢的改善效果研究[J]. 茶叶科学, 2022, 42(4): 561-576. doi: 10.13305/j.cnki.jts.2022.04.010.

SUN Ying, CHEN Xin, YANG Hua, YING Jian, SHAO Danqing, LÜ Xiaohua, XIAO Jie, CHEN Zhixiong, LI Song, QIN Junjie, ZHENG Bin, GAO Jianshe. Clinical Trial on the Effect of Drinking Jinhua Xiangyuan Tea for 3 Months on the Improvement of Glucose and Lipid Metabolism in A Small Sample Hyperlipidemia Population[J]. Journal of Tea Science, 2022, 42(4): 561-576. doi: 10.13305/j.cnki.jts.2022.04.010.

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饮用金花香橼茶3个月对小样本高脂血症人群糖脂代谢的改善效果研究

Clinical Trial on the Effect of Drinking Jinhua Xiangyuan Tea for 3 Months on the Improvement of Glucose and Lipid Metabolism in A Small Sample Hyperlipidemia Population

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