EGCG纳米载体制备技术及其对EGCG活性影响的研究进展

摘要/Abstract

摘要： 表没食子儿茶素没食子酸酯（EGCG）是绿茶中最重要的生物活性成分,在肿瘤形成的各个阶段都有抑癌活性。纳米化途径是提高EGCG稳定性和生物利用度的有效技术之一。已有较多的研究表明,多类材料可用于制备纳米粒子作为EGCG载体,并在改善EGCG生物活性方面效果显著。本文按制备纳米粒子主要材料的不同,对各类纳米粒子的制备方法、特性及其在改善EGCG的生物活性方面的研究进行了分述,并对各种纳米粒的增效作用进行了归纳总结。

关键词: EGCG, 纳米粒, 材料, 制备, 生物有效性

Abstract: (-)-Epigallocatechin gallate (EGCG) is one of the most important bioactive compounds in green tea, which has shown antitumor activity in various stages of tumor formation. Loading EGCG in nano-carriers is an effective technique to improve the stability and bioavailability of EGCG. Many studies had shown that various kinds of materials can be used for the preparation of nanoparticles as a EGCG nano-carrier, which significantly improved the biological activity of EGCG. The preparation methods, characteristics and the biological activity of EGCG nano-carrier were reviewed, and the improvement of effectiveness by EGCG nanoparticles formulation was also dicussed.

Key words: (-)-Epigallocatechin gallate, nano-carrier, material, preparation, bioavailability

中图分类号:

祁洁, 徐颖磊, 梁文怡, 费朵, 乌昕儿, 金建昌, 杜琪珍, 许勇泉, 高颖. EGCG纳米载体制备技术及其对EGCG活性影响的研究进展[J]. 茶叶科学, 2017, 37(2): 119-129.

QI Jie, XU Yinglei, LIANG Wenyi, FEI Duo, WU Xiner, JIN Jianchang, DU Qizhen, XU Yongquan, GAO Ying. Progress on the Preparation Technologies and the Active Improvement of EGCG Nano-carriers[J]. Journal of Tea Science, 2017, 37(2): 119-129.

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