红茶提取物对高尿酸血症小鼠血尿酸的影响

茶叶科学 ›› 2017, Vol. 37 ›› Issue (2): 167-172.

红茶提取物对高尿酸血症小鼠血尿酸的影响

朱创^1,2, 刘增辉³, 赵永青^1,2, 邰玲玲^1,2, 徐燕^1,2,*

1. 安徽农业大学茶与食品科技学院,安徽合肥 230036;
2. 茶树生物学与资源利用国家重点实验室,安徽合肥 230036;
3. 安徽省医学科学研究院,安徽合肥 230061

收稿日期:2016-12-26 修回日期:2017-01-17 出版日期:2017-04-15 发布日期:2019-08-22
通讯作者: *yanxu@ahau.edu.cn
作者简介:朱创,女,硕士研究生,主要从事茶天然产物与健康研究。
基金资助:
2017安徽省高等学校自然科学基金（kj2017A128）、安徽省科技重大专项项目（15czz03116）、安徽省茶叶化学与健康领军人才团队引进重大示范项目资助

Effects of Black Tea Extract on Serum Uric Acid Levels in Hyperuricemic Mice

ZHU Chuang^1,2, LIU Zenghui³, ZHAO Yongqing^1,2, TAI Lingling^1,2, XU Yan^1,2,*

1. School of Tea & Food Science, Anhui Agricultural University, Hefei 230036, China;;
2. State Key Laboratory of Tea Biology and Utilization, Hefei 230036, China;
3. Anhui Academy of Medical Science, Hefei 230061, China

Received:2016-12-26 Revised:2017-01-17 Online:2017-04-15 Published:2019-08-22

摘要/Abstract

摘要： 研究红茶提取物对高尿酸血症小鼠血尿酸的影响。将36只雄性KM小鼠随机分为空白组、模型组、红茶提取物低、中、高剂量组及别嘌呤醇组。空白组和给茶组连续1周分别灌胃生理盐水和红茶提取物,给茶组第7天造模后1βh给茶;模型组在第7天腹腔注射氧嗪酸钾并灌胃酵母膏造模。测定结果显示：与模型组相比,各给茶组血尿酸（UA）水平均降低;与模型组相比,给茶组血尿素氮（BUN）水平均降低,其中、高剂量给茶组BUN水平显著降低（P<0.05）,高剂量组差异极显著（P<0.01）;各给茶组血肌酐（Cr）值与模型组相比极显著下降（P<0.001）。高剂量组黄嘌呤氧化酶（XOD）活性较模型组显著降低（P<0.05）,低、中剂量组有一定的抑制作用,但无显著差异。研究表明,红茶提取物对氧嗪酸钾和酵母膏导致的小鼠高尿酸血症有明显的改善作用。

关键词: 红茶提取物, 高尿酸血症, 尿酸, 黄嘌呤氧化酶

Abstract: This study was aimed to investigate the effect of black tea extract on the level of serum uric acid in hyperuricemic mice. Thirty six KM male mice were randomly divided into the control group, model group, tea-treated low dose group, middle dose group, high dose group and allopurinol group. Mice in the control group and tea-treated groups were treated with saline and black tea extract respectively for consecutive 7 days. The later were given black tea extract 1 hour after modeling on the seventh day. The model group was given PO through intraperitoneal injection and yeast extract intragastrically to establish model on the seventh day. The results showed that compared with the model group, the levels of serum UA and BUN (blood urea nitrogen) were decreased in tea-treated groups, with significant decreases in the middle (P<0.05) and high dose groups (P<0.01). The serum Cr level (creatinine) of tea-treated groups were decreased and the XOD activity in the high dose group was significantly lower than those in the model group (P<0.05). there were slight but not significantly inhibitory effect in the low and middle dose groups. These date suggest that black tea extract possesses significant anti-hyperuricemic effect on hyperuricemic mice induced by PO and yeast extract.

Key words: black tea extract, hyperuricemia, uric acid, xanthine oxidase

中图分类号:

朱创, 刘增辉, 赵永青, 邰玲玲, 徐燕. 红茶提取物对高尿酸血症小鼠血尿酸的影响[J]. 茶叶科学, 2017, 37(2): 167-172.

ZHU Chuang, LIU Zenghui, ZHAO Yongqing, TAI Lingling, XU Yan. Effects of Black Tea Extract on Serum Uric Acid Levels in Hyperuricemic Mice[J]. Journal of Tea Science, 2017, 37(2): 167-172.

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