Abstract: To explore the anti-hypertension effect of Pu-erh tea extract on SHR. Pu-erh tea extract was administered to SHR for 4 weeks with 0.25, 0.5, 1.0, 2.0g/kg doses. The blood pressure and heart rate of animals were measured once every week, and the body weight was also measured weekly in the research. Results showed that the mean blood pressure, systolic pressure and diastolic pressure of spontaneous hypertension rats were significantly reduced in the treatment with 1.0g/kg and 2.0g/kg Pu-erh tea extract, compared with that of model group(P<0.01). The body weight of animal in 2.0g/kg Pu-erh tea extract group was lower when compared with model group, but the heart rate of this group was higher than model group. The heart rate and the increase of body weight of tested animal in the other dose group were non-significantly difference. Conclusions: The Pu-erh tea extract shows dose-dependent antihypertensive effect in spontaneous hypertension rats.

Key words: Pu-erh tea extract, anti-hypertension, spontaneous hypertension rats