茶氨酸对ICR小鼠免疫功能的影响及其急性毒性初步研究

doi:10.13305/j.cnki.jts.2011.01.003

Abstract

Abstract: The effect of theanine on immuno-enhancement ability was evaluated. Results showed that theanine nearly has no impact on mice immune organs. And theanine could effectively enhance the clearing ability of mice. Theanine could also effectively increase the DTH of mice in DNFB induced tests (all does groups being higher compare with the model does), and especially, the high does increased most. The maximal tolerance dose (MTD) on theanine is more than 20.0g/kg, which illustrate theanine is non-toxic.

Key words: theanine, immuno-enhancement, acute toxicity

CLC Number:

TS272
R392.3

TAN Jun-feng, LI Liang, HE Pu-ming, LV Hai-peng, GUO Li, LIN Zhi. Effect of Theanine’s Immuno-enhancement and Acute Toxicity Based on ICR Mice[J]. Journal of Tea Science, 2011, 31(1): 17-21.

References

[1] 李敏, 沈新南, 姚国英. 茶氨酸延缓运动性疲劳及其作用机制研究[J]. 营养学报, 2005, 27(4): 326-329.
[2] 吕毅, 郭霞飞, 倪捷儿, 等. 茶氨酸的生理作用及合成[J]. 茶叶科学, 2003, 23(1): 1-5.
[3] 林雪玲, 程朝辉, 黄才欢, 等. 茶氨酸对小鼠学习记忆能力的影响[J]. 食品科学, 2004, 25(5): 171-173.
[4] 刘显明, 李月芬, 李国平. 茶氨酸对D2半乳糖衰老模型小鼠抗衰老作用的实验研究[J]. 创伤外科杂志, 2008, 10(3): 257-259.
[5] 小林加奈理. L-テアニンのヒトの脑波に及ぼす影响[J]. 日本農芸化學會志, 1998(72): l53-l57.
[6] 林智. 从茶叶抗病毒的研究谈茶氨酸的生产与应用前景[J]. 中国茶叶, 2003, 35(3): 4-5.
[7] Bukowski J F, Percival S S.L-theanine intervention enhances human gamma delta T lymphocyte function[J]. Nutrition reviews, 2008, 66(2): 96-102.
[8] Kamath A B, Wang L, Das H, et al. Antigens in tea-beverage prime human vγ2vδ2T cell in vitro and in vivo for memory and nonmemory antibacterial cytokine responses[J]. Proc Natl Acad Sci, 2003, 100(10): 6009-6014.
[9] 胡柏平, 洪涛. 茶氨酸的生理作用及与运动的关系[J]. 四川体育科学, 2006, 6(2): 27-30.
[10] 王小雪, 邱隽, 宋宇, 等. 茶氨酸的抗疲劳作用研究[J]. 中国公共卫生, 2002, 18(3): 315-317.
[11] 王玉芬, 秦志祥, 唐振山, 等. 茶氨酸对家兔脑缺血后IL-8和NSE及脑超微结构的影响[J]. 中国医师杂志, 2007, 9(1): 4-6.
[12] 王玉芬, 李春雨, 秦志祥, 等. 茶氨酸对脑缺血再灌注损伤保护作用的实验研究[J]. 中华神经医学杂志, 2006, 5(6): 562-565.
[13] 李靓, 林智, 何普明, 等. 茶氨酸改善小鼠睡眠状况的实验研究[J]. 食品科学, 2009, 30(15): 214-216.
[14] 张红城, 董捷, 胡余明. 蜂王浆咀嚼片增强免疫力功能实验研究[J]. 食品科学, 2008, 29(8): 579-583.
[15] 中华人民共和国卫生部. 保健食品检验与评价技术规范: 2003年版[M]//全国人大常委会法制工作委员会. 食品法律法规文件汇编. 北京: 化学工业出版社, 2005.
[16] 周素娟, 黄璐琦, 杜贵友. 参类保健食品情况分析及有关技术审评的几点建议[J]. 中国中药杂志, 2008, 33(5): 615-616.

Effect of Theanine’s Immuno-enhancement and Acute Toxicity Based on ICR Mice

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10

[1]	HUANG Qiuping, XIE Chenyang, LI Xinyu, JIN Bin, ZENG Zhen, QIAN Bo, DAI Ling, SONG Jiale. L-Theanine Ameliorated Clinical Symptoms in Letrozole-Induced Polycystic Ovary Syndrome Rats [J]. Journal of Tea Science, 2021, 41(6): 831-842.
[2]	CHEN Meiyan, LIU Fen, LIN Yong, ZUO Gaolong, ZUO Yingpeng, LIU Zhonghua. Intervention Effects of L-Theanine on the Damage of Hippocampus and Gut in CUMS Depressed Rats [J]. Journal of Tea Science, 2021, 41(4): 511-524.
[3]	MAO Peng, WANG Liyuan, BAI Peixian, WEI Kang, RUAN Li, ZHNAG Yazhen, CHENG Hao. Identification and Analysis of Analogue Theanine Synthase Gene Family in Tomato [J]. Journal of Tea Science, 2021, 41(2): 173-183.
[4]	JIN Ke, HUANG Jian'an, XIONG Ligui, LIU Shuoqian, QIN Xiaohong, PENG Jing, LI Yinhua, LI Juan. Research of Theanine-related Genes Expressed in Etiolated Tea Plant (Camellia Sinensis) [J]. Journal of Tea Science, 2021, 41(1): 40-47.
[5]	ZENG Li, XIAO Wenjun. Advances in Brain Diseases Prevention and Treatment of L- theanine [J]. Journal of Tea Science, 2019, 39(2): 193-202.
[6]	PENG Yingqi, XIAO Wenjun, ZHANG Sheng, YUAN Dongyin, LIN Ling, ZHOU Yang, GONG Zhihua. Effects of L-theanine on Intestinal Morphology and Free Amino Acids in Mice [J]. Journal of Tea Science, 2019, 39(1): 43-54.
[7]	ZHU Chengbo, WU Xiaomei, FENG Lixia, HUANG Xiangpeng, PANG Linjiang, YANG Huqing, FANG Zhengwei, WANG Ying, LAI Shuyu, ZHANG Yiming. Rapid Detection of Theanine in Green Tea Based on Direct-reading Colorimetric Strips [J]. Journal of Tea Science, 2018, 38(3): 244-252.
[8]	LI Xiaojie, MA Jianqiang, YAO Mingzhe, CHEN Liang. SNP Detection and Mapping of Theanine Synthetase Gene in Tea Plant [J]. Journal of Tea Science, 2017, 37(3): 251-257.
[9]	WU Wenliang, LIN Yong, LIU Zhonghua, HUANG Jian'an, LONG Zhirong, TENG Cuiqing, MA Shicheng, QIU Ruijin, CAO Zhonghuan. Research on Acute and Subacute Toxicity Evaluation of Liupao Tea [J]. Journal of Tea Science, 2017, 37(2): 173-181.
[10]	GUO Chen, LIU Linfeng, XIANG Yi, LUO Li, LIN Ling, XIAO Wenjun. L-theanine Attenuates Tissue and Oxidative Damages in Heat Stressed Mice [J]. Journal of Tea Science, 2017, 37(1): 17-24.
[11]	LIU Zunying, LIU Qiuling, DENG Yanli, CHEN Ling, XIAO Wenjun. Study on the Protective Effect of L-Theanine on the Intestinal in Mice with Immune Stress Induced by ETEC [J]. Journal of Tea Science, 2016, 36(5): 469-476.
[12]	LIU Qiuling, GONG Zhihua, CHENG Ling, LIU Zunying, DENG Yanli, CHEN Dong, XIAO Wenjun. Study on the Protective Effect of L-Theanine on the Liver of Mice with Immune Stress Induced by ETEC [J]. Journal of Tea Science, 2016, 36(5): 484-490.
[13]	PENG Bin, LIU Zhonghua, LIN Yong, LIN Haiyan, HUANG Jian'an. The Ameliorative Effect of L-theanine on Chronic Unpredictable Mild Stress-induced Depression in Rats [J]. Journal of Tea Science, 2014, 34(4): 355-363.
[14]	LIU Xiaohui, JIE Guoliang, LIN Kang, WU Yuanyuan, WANG Yuefei, TU Youying. Research on Synergistic Protection and Repairing Effects of EGCG and Theanine in Oxidative Damaged Cells [J]. Journal of Tea Science, 2014, 34(3): 239-247.
[15]	YU Xi-chong, YANG Wei, WU Bo-la. Theanine Depressed the Food Intake and Gastric Emptying in Female Mice via Lateral Hypothalamic AMPA and NMDA Receptor [J]. Journal of Tea Science, 2013, 33(5): 429-435.