甲基化EGCG的研究现状及展望

doi:10.13305/j.cnki.jts.2010.06.001

Abstract

Abstract: EGCG3"Me was first isolated from green tea in 1982, and its potential antiallergic activity was reported. In recent years, some other methylated EGCG were discovered in tea or vivo metabolites. The isolation, function and synthesis of methylated EGCG were reviewed in this paper. The separation methods of methylated EGCG including Sephadex LH-20 chromatography, high-speed countercurrent chromatography, Toyopearl HW-40S medium-pressure chromatography, and preparative high performance liquid chromatography(pHPLC) were summarized. Compared to the biological activities of EGCG, the methylated form showed the higher activities in anti-allergy, anti-cytotoxin, lipoxygenase inhibition and inducible nitric oxide synthase(iNOS) inhibition, and liver cells protection. The synthesis of methylated EGCG include chemical synthesis and biosynthesis.

Key words: methylated EGCG, isolation, biological activity, synthesis

CLC Number:

WU Yan-jun, WANG Xiao-gang, WAN Xiao-chun. Present Studies and Research Prospects on the Methylated EGCG[J]. Journal of Tea Science, 2010, 30(6): 407-413.

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Present Studies and Research Prospects on the Methylated EGCG

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