狭叶茶提取物对小鼠氧化应激性肝损伤的保护作用

doi:10.13305/j.cnki.jts.2008.02.013

Abstract

Abstract: To investigate the protective effect of Camellia angustifolia Chang extracts (CA. extracts) on restraint stress-induced liver damage in mice, The mice model of stress-induced liver damage was used in investigation. After 18βh restraint stress on mice 4 days following CA. extracts treatment, the liver damage was established. Alanine aminotransferase (ALT) and xanthine oxidase(XOD)activities, malondialdehyde (MDA) contents, GSH levels, GPX and GST activities, as well as oxygen radical absorbance capacity (ORAC) values in liver were determined to evaluate the hepatoprotective effects. Compared with restraint model group, CA. extracts can markedly reduce ALT activities, MDA contents and XOD activities, protect the liver damage induced by oxidative stress. Additionally, CA. extracts can effectively increase the ORAC values both in vivo and in vitro, as well as GSH levels, GPX activities and GST activities. Oral treatment of CA. extracts was found to reduce restrain-stress-induced liver damage in terms of above mentioned biochemical parameters, it is considered that this protective effects may be related to its free radical scavenging activity and lipid peroxidation inhibitory effects.

Key words: Camellia angustifolia Chang, restraint stress, oxidative stress, oxygen radical absorbance capacity

CLC Number:

TS272

GU Chen-fei, BAO Li, XIE Guo, LU Yan-qing, YAO xin-sheng, Kurihara Hiroshi. Protective Effects of Camellia angustifolia Chang on Oxidative Stress-induced Liver Damage in Mice[J]. Journal of Tea Science, 2008, 28(2): 115-122.

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Protective Effects of Camellia angustifolia Chang on Oxidative Stress-induced Liver Damage in Mice

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