儿茶素对ECV304细胞增殖和迁移的影响

doi:10.13305/j.cnki.jts.2005.02.004

Abstract

Abstract: By employing techniques of cell culture, the effects of four tea catechins, EGCG, ECG, EC and C were investigated on the proliferation and migration of ECV304 by the authors. The result demonstrated that EGCG was the most effective in cell viability among the four tested catechins. Viability of ECV304 were significantly different in the case of the concentrations of EGCG ,which was ranged from 50 to 150 μmol/L. The IC50 of EGCG was 75~150 μmol/L, EGCG was also effective in cell migration in a dose dependent manner, the IC50 was 150 μmol/L. EGCG could inhibit angiogensis, which may be related to the decreased migration of endothelial cell. The IC50 was at 390 μmol/L and 370 μmol/L in 36 hour-disposal and 48 hour-disposal of ECG respectively. The viability of ECV304 disposed by C and EC were above 80%. It was indicated that catechins showed insignificant inhibitory effect on normal cell growth and migration at the concentration of lower than 75 μmol/L.

Key words: Tea catechins, ECV304 cell, Cell viability, Cell migration

CLC Number:

ZHANG Yu-yan, SHEN Sheng-rong. Effects of Catechins on the Proliferation and Migration of ECV304 Cell[J]. Journal of Tea Science, 2005, 25(2): 100-108.

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Effects of Catechins on the Proliferation and Migration of ECV304 Cell

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