茶多糖调控肥胖作用研究进展

doi:10.13305/j.cnki.jts.2020.05.001

Abstract

Abstract: With the improvement of people's living standards, the incidence of obesity has been rising, which has become a serious health problem of the society. Tea polysaccharide, as an acid heteropolysaccharide combined with protein, can regulate food intake and energy absorption, regulate adipogenesis, enhance antioxidant defense enzyme activities and reduce inflammation, regulate intestinal flora disorders and maintain different pathways such as intestinal barrier integrity, thereby effectively regulates obesity. The regulation mechanism of tea polysaccharides on obesity was reviewed based on the researches in recent years.

Key words: tea polysaccharide, obesity, regulation, mechanism of action

CLC Number:

OUYANG Jian, ZHOU Fang, LU Danmin, LI Xiuping, HUANG Jian'an, LIU Zhonghua. Research Progress of Tea Polysaccharides in Regulating Obesity[J]. Journal of Tea Science, 2020, 40(5): 565-575.

References 75

[1]	Breda J, Jewell J, Keller A.The importance of the World Health Organization sugar guidelines for dental health and obesity prevention[J]. Caries Research, 2019, 53: 149-152.
[2]	Silvia B S, Ana O R, Mirjam M H, et al.Clustering of multiple energy balance-related behaviors in school children and its association with overweight and obesity: WHO European Childhood Obesity Surveillance Initiative (COSI 2015-2017)[J]. Nutrients, 2019, 11(3): 511. doi: 10.3390/nu11030511.
[3]	Ezzati M, Bentham J, Di C M, et al.Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults[J]. Lancet, 2017, 390(10113): 2627-2642.
[4]	马冠生. 中国儿童肥胖报告[R]. 北京: 人民卫生出版社, 2017.Ma G S.Report on childhood obesity in china [R]. Beijing: People's Medical Publishing House, 2017.
[5]	Guida S, Venema K.Gut microbiota and obesity: involvement of the adipose tissue[J]. Journal of Functional Foods, 2015, 14: 407-423.
[6]	Guh D P, Zhang W, Bansback N, et al.The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis[J]. BMC Public Health, 2009, 9: 88. doi: 10.1186/1471-2458-9-88.
[7]	Piche M E, Poirier P, Lemieux I, et al.Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update[J]. Progress Cardiovasc Diseases, 2018, 61(2): 103-113.
[8]	Lee E Y, Yook K H.Epidemic obesity in children and adolescents: risk factors and prevention[J]. Front Med, 2018, 12(6): 658-666.
[9]	Chen G, Chen R, Chen D, et al.Tea polysaccharides as potential therapeutic options for metabolic diseases[J]. Journal of Agricultural and Food Chemistry, 2018, 67(19): 5350-5360.
[10]	Guirro M, Herrero P, Costa A, et al.Comparison of metaproteomics workflows for deciphering the functions of gut microbiota in an animal model of obesity[J]. Journal of Proteomics, 2019, 209: 103489. doi: 10.1016/j.jprot.2019.103489.
[11]	Song D, Cheng L, Zhang X, et al.The modulatory effect and the mechanism of flavonoids on obesity[J]. Journal of Food Biochemistry, 2019, 43(8): e12954. doi: 10.1111/jfbc.12954.
[12]	李海珊, 刘丽乔, 聂少平. 茶多糖对小鼠肠道健康及免疫调节功能的影响[J]. 食品科学, 2017, 38(7): 187-192.Li H S, Liu L Q, Nie S P.Effects of green tea polysaccharides on intestinal health and immune regulation in mice[J]. Food Science, 2017, 38(7): 187-192.
[13]	Yang C S, Zhang J, Zhang L, et al.Mechanisms of body weight reduction and metabolic syndrome alleviation by tea[J]. Molecular Nutrition & Food Research, 2016, 60(1): 160-174.
[14]	Wu T, Guo Y, Liu R, et al.Black tea polyphenols and polysaccharides improve body composition, increase fecal fatty acid, and regulate fat metabolism in high-fat diet-induced obese rats[J]. Food Function, 2016, 7(5): 2469-2478.
[15]	Nakamura M, Miura S, Takagaki A, et al.Hypolipidemic effects of crude green tea polysaccharide on rats, and structural features of tea polysaccharides isolated from the crude polysaccharide[J]. International Journal Food Science Nutrients, 2017, 68(3): 321-330.
[16]	Li S, Chen H, Wang J, et al.Involvement of the PI3K/Akt signal pathway in the hypoglycemic effects of tea polysaccharides on diabetic mice[J]. International Journal Biological Macromolecules, 2015, 81: 967-974.
[17]	Chen H, Wang Z, Qu Z, et al.Physicochemical characterization and antioxidant activity of a polysaccharide isolated from oolong tea[J]. European Food Research and Technology, 2009, 229(4): 629-635.
[18]	艾于杰. 抗氧化活性茶多糖构效关系研究[D]. 武汉: 华中农业大学, 2019.Ai Y J.Study on the structure-activity relationship of antioxidant polysaccharides [D]. Wuhan: Huazhong Agricultural University, 2019.
[19]	邵淑宏. 乌龙茶多糖理化性质及抗氣化、降血糖活性研究[D]. 杭州: 浙江大学, 2015.Shao S H.Study on physical and chemical properties of dragon tea polysaccharide and its anti-gasification and hypoglycemic activity [D]. Hangzhou: Zhejiang University, 2015.
[20]	Chen H, Zhang M, Qu Z, et al.Antioxidant activities of different fractions of polysaccharide conjugates from green tea (Camellia Sinensis)[J]. Food Chemistry, 2008, 106(2): 559-563.
[21]	李娟, 刘锐, 吴涛, 等. 不同茶多糖对3T3-L1前脂肪细胞分化的抑制作用比较[J]. 食品科学, 2017, 38(21): 187-193.Li J, Liu R, Wu T, et al.Comparison of the inhibitory effects of different tea polysaccharides on the differentiation of 3T3-L1 preadipocytes[J]. Food Science, 2017, 38(21): 187-193.
[22]	刘海燕, 任发政, 李景明, 等. 几种植物多糖的结构特征与预防肥胖活性研究[J]. 中国食物与营养, 2019, 25(12): 44-51.Liu H Y, Ren F Z, Li J M, et al.Structural characteristics and anti-obesity efficacy of several plant polysaccharides[J]. Food and Nutrition in China, 2019, 25(12): 44-51.
[23]	Chen G, Wang M, Xie M, et al.Evaluation of chemical property, cytotoxicity and antioxidant activity in vitro and in vivo of polysaccharides from Fuzhuan brick teas[J]. International Journal Biological Macromolecules, 2018, 116: 120-127.
[24]	Chen H X, Zhang M, Qu Z S.Compositional analysis and preliminary toxicological evaluation of a tea polysaccharide conjugate[J]. Journal of Agricultural and Food Chemistry, 2007, 55: 2256-2260.
[25]	韦铮, 贺燕, 郝麒麟, 等. 茶多糖在模拟胃肠消化体系的抗氧化作用研究[J]. 食品与发酵工业, 2020, 46(10): 109-117.Wei Z, He Y, Hao Q L, et al.Study on the antioxidant effect of tea polysaccharides under the conditions of simulating gastrointestinal digestion in vitro[J]. Food and Fermentation Industries, 2020, 46(10): 109-117.
[26]	Chen G J, Xie M H, Wan P, et al.Digestion under saliva, simulated gastric and small intestinal conditions and fermentation in vitro by human intestinal microbiota of polysaccharides from Fuzhuan brick tea[J]. Food Chemistry, 2018, 244: 331-339.
[27]	Li W W, Wang C, Yuan G Q, et al.Physicochemical characterisation and α-amylase inhibitory activity of tea polysaccharides under simulated salivary, gastric and intestinal conditions[J]. International Journal of Food Science & Technology, 2018, 53(2): 423-429.
[28]	Fernández J, Redondo-B S, Gutiérrez-del R I, et al. Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review[J]. Journal of Functional Foods, 2016, 25: 511-522.
[29]	张高帆, 陈萍, 徐思绮, 等. 茶多糖对四氧嘧啶模型小鼠的降糖作用及其体内分布规律研究[J]. 营养学报, 2015, 37(4): 384-388.Zhang G F, Chen P, Xu S Q, et al.Hypoglycemic effect of tea polysaccharide on alloxan model mice and its in vivo research on distribution law[J]. Journal of Nutrition, 2015, 37(4): 384-388.
[30]	Sánchez J, Priego T, Palou M, et al.Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life[J]. Endocrinology, 2008, 149(2): 733-740.
[31]	杨志秋, 詹莉莉, 傅正伟. 脂肪酶抑制剂应用于抗肥胖的研究进展[J]. 现代生物医学进展, 2011, 11(21): 4178-4181.Yang Z Q, Zhan L L, Fu Z W.Recent advances of lipase inhibitor in the application of anti-obesity[J]. Progress in Modern Biomedicine, 2011, 11(21): 4178-4181.
[32]	李祥龙, 李晓梅, 杨煦, 等. 黑茶茶褐素与茶多糖对脂肪酶的抑制作用[J]. 食品与机械, 2018, 34(3): 27-31, 58.Li X L, Li X M, Yang X, et al.Study of inhibition of black tea theabrownin and tea polysaccharides on lipase[J]. Food and Machinery, 2018, 34(3): 27-31, 58.
[33]	舒婷, 肖畅, 何慧, 等. 青砖茶粗多糖抑制α-葡萄糖苷酶活性的研究[J]. 食品科技, 2019, 44(3): 194-199.Shu T, Xiao C, He H, et al.Inhibitory effects of crude polysaccharide of green brick tea on α-glucosidase activity[J]. Food Science and Technology, 2019, 44(3): 194-199.
[34]	和兴萍, 罗燕, 李雪, 等. 几种降脂减肥实验动物模型的建立与比较[J]. 中华中医药学刊, 2017, 35: 1747-1751.He X P, Luo Y, Li X, et al.Comparison of several kinds of lipid-Lowering diet experimental animal model[J]. Chinese Journal of Traditional Chinese Medicine, 2017, 35: 1747-1751.
[35]	陈粉粉, 郭爱伟, 周杰珑, 等. ICR小鼠肥胖模型的建立以及肥胖指标和脂肪组织形态学比较[J]. 安徽农业科学, 2012, 40(5): 2720-2073.Chen F F, Guo A W, Zhou J L, et al.Establishment of the obesity model of ICR mice and the comparison of the obesity index and morphology of adipose tissue[J]. Journal of Anhui Agri, 2012, 40(5): 2720-2073.
[36]	Ren D, Hu Y, Luo Y, et al.Selenium-containing polysaccharides from Ziyang green tea ameliorate high-fructose diet induced insulin resistance and hepatic oxidative stress in mice[J]. Food Function, 2015, 6(10): 3342-3350.
[37]	李清亮. 黄大茶茶多糖对饲喂高脂日粮小鼠肠道菌群的调节作用[D]. 合肥: 安徽农业大学, 2018.Li Q L.Polysacchardies in Large Yellow tea modulate gut microbiome in HFD fed mice [D]. Hefei: Anhui Agricultural University, 2018.
[38]	Mao Y, Wei B, Teng J, et al.Polysaccharides from Chinese Liupao dark tea and their protective effect against hyperlipidemia[J]. International Journal of Food Science & Technology, 2018, 53(3): 599-607.
[39]	郭郁, 吴涛, 刘锐, 等. 红茶提取物减肥作用研究[J]. 现代食品科技, 2017, 33(2): 16-21.Guo Y, Wu T, Liu R, et al.Study on the weight-loss effect of black tea extracts[J]. Modern Food Science and Technology, 2017, 33(2): 16-21.
[40]	吴文华. 洱茶调节血脂功能评价及其生化机理的研究[D] . 重庆: 西南农业大学, 2003.Wu W H.Functional appraisal of blood lipid adjusted by Puer tea and study on its physiochemical mechanism [D]. Chongqing: Southwest Agricultural University, 2003.
[41]	Olsen M K, Johannessen H, Cassie N, et al.Steady-state energy balance in animal models of obesity and weight loss[J]. Scandinavian Journal Gastroenterology, 2017, 52(4): 442-449.
[42]	Ahima R S, Antwi D A.Brain regulation of appetite and satiety[J]. Endocrinology and Metabolism Clinics of North America, 2008, 37(4): 811-823.
[43]	Xu Y, Zhang M, Wu T, et al.The anti-obesity effect of green tea polysaccharides, polyphenols and caffeine in rats fed with a high-fat diet[J]. Food Function, 2015, 6(1): 297-304.
[44]	Maniadakis N, Kapaki V, Damianidi L, et al.A systematic review of the effectiveness of taxes on nonalcoholic beverages and high-in-fat foods as a means to prevent obesity trends[J]. ClinicoEconomics and Outcomes Research, 2013, 5: 519-543.
[45]	Huang J, Wang Y, Xie Z, et al.The anti-obesity effects of green tea in human intervention and basic molecular studies[J]. European Journal Clinical Nutrition, 2014, 68(10): 1075-1087.
[46]	Chung J O, Yoo S H, Lee Y E, et al.Hypoglycemic potential of whole green tea: water-soluble green tea polysaccharides combined with green tea extract delays digestibility and intestinal glucose transport of rice starch[J]. Food & Function, 2019, 10(2): 746-753.
[47]	Saely C H, Geiger K, Drexel H.Brown versus white adipose tissue: a mini-review[J]. Gerontology, 2012, 58(1): 15-23.
[48]	Frühbeck G, Becerril S, Sáinz N, et al.BAT: A new target for human obesity?[J]. Trends in Pharmacological Sciences, 2009, 30(8): 387-396.
[49]	Ferranti S, Mozaffarian D.The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences[J]. Clinical Chemistry, 2008, 54(6): 945-955.
[50]	Hammad S S, Eck P, Sihag J, et al.Common variants in lipid metabolism-related genes associate with fat mass changes in response to dietary monounsaturated fatty acids in adults with abdominal obesity[J]. The Journal of Nutrition, 2019, 149(10): 1749-1756.
[51]	Bazhan N M, Baklanov A V, Piskunova J V, et al.Expression of genes involved in carbohydrate-lipid metabolism in muscle and fat tissues in the initial stage of adult-age obesity in fed and fasted mice[J]. Physiological Reports, 2017, 5(19): e13445. doi: 10.14814/phy2.13445.
[52]	Catalán V, Rodríguez A, Ramírez B, et al.Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity[J]. Nutrition Metabolism & Cardiovascular Diseases, 2017, 21(4): 245-253.
[53]	Chen G J, Xie M H, Wan P, et al.Fuzhuan brick tea polysaccharides attenuate metabolic syndrome in high-fat diet induced mice in association with modulation in the gut microbiota[J]. Journal of Agricultural and Food Chemistry, 2018, 66(11): 2783-2795.
[54]	Manna P, Jain S K.Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies[J]. Metabolic Syndrome And Related Disorders, 2015, 13(10): 423-444.
[55]	Fernandez S A, Madrigal S E, Bautista M, et al.Inflammation, oxidative stress, and obesity[J]. International Journal of Molecular Sciences, 2011, 12(5): 3117-3132.
[56]	Savini I, Catani M V, Evangelista D, et al.Obesity-associated oxidative stress: strategies finalized to improve redox state[J]. International Journal of Molecular Sciences, 2013, 14(5): 10497-10538.
[57]	Wang J, Liu W, Chen Z, et al.Physicochemical characterization of the oolong tea polysaccharides with high molecular weight and their synergistic effects in combination with polyphenols on hepatocellular carcinoma[J]. Biomed Pharmacother, 2017, 90: 160-170.
[58]	Wang Y, Zhao Y, Andrae M K, et al.Tea polysaccharides as food antioxidants: an old woman's tale?[J]. Food Chemistry, 2013, 138(2/3): 1923-1927.
[59]	Zhang L, Gui S, Liang Z, et al.Musca domestica cecropin (Mdc) alleviates Salmonella typhimurium-induced colonic mucosal barrier impairment: associating with inflammatory and oxidative stress response, tight junction as well as intestinal flora[J]. Frontiers in Microbiology, 2019, 10: 522. doi: 10.3389/fmicb.2019.00522.
[60]	Musso G, Gambino R, Cassader M.Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes[J]. The Annual Review of Medicine, 2011, 62: 361-380.
[61]	Huang F, Zheng X, Ma X, et al.Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism[J]. Nature Communications, 2019, 10(1): 4971. doi: 10.1038/s41467-019-12896-x.
[62]	Rothschild D, Weissbrod O, Barkan E, et al.Environment dominates over host genetics in shaping human gutmicrobiota[J]. Nature, 2018, 555: 210-215.
[63]	Rosenbaum M, Knight R, Leibel R L.The gut microbiota in human energy homeostasis and obesity[J]. Trends Endocrinol Metab, 2015, 26(9): 493-501.
[64]	Bernardi S, Del Bo C, Marino M, et al.Polyphenols and intestinal permeability: rationale and future perspectives[J]. Journal of Agricultural and Food Chemistry, 2020, 68(7): 1816-1829.
[65]	Dugas L R, Lie L, Plange-Rhule J, et al.Gut microbiota, short chain fatty acids, and obesity across the epidemiologic transition: the METS-Microbiome study protocol[J]. BMC Public Health, 2018, 18(1): 978. doi: 10.1186/s12889-018-5879-6.
[66]	Tremaroli V, Backhed F.Functional interactions between the gut microbiota and host metabolism[J]. Nature, 2012, 489(7415): 242-249.
[67]	Petriz B A, Castro A P, Almeida J A, et al.Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats[J]. BMC Genomics, 2014, 15: 511. doi: 10.1186/1471-2164-15-511.
[68]	Queipo M I, Seoane L M, Murri M, et al.Gut microbiota composition in male rat models under different nutritional status and physical activity and its association with serum leptin and ghrelin levels[J]. Plos One, 2013, 8(5): e65465. doi: 10.1371/journal.pone.0065465.
[69]	Wahlström A, Sayin S I, Marschall H U, et al.Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism[J]. Cell Metabolism, 2016, 24(1): 41-50.
[70]	Chen H, Qu, Z, Fu L L, et al. Physicochemical properties and antioxidant capacity of 3 polysaccharides from green tea, oolong tea, and black tea[J]. Journal of Food Science, 2009, 74(6): 469474. doi: 10.1111/j.1750-3841.2009.01231.x.
[71]	Chen H X, Zhang M, Qu Z S, et al.Antioxidant activities of different fractions of polysaccharide conjugates from green tea (Camellia sinensis)[J]. Food Chemistry, 2008, 106: 559-563.
[72]	Du L L, Fu Q Y, Xiang L P, et al.Tea polysaccharides and their bioactivities[J]. Molecules, 2016, 21(11): 1449. doi: 10.3390/molecules21111449.
[73]	Wang Y F, Liu Y Y, Huo J L, et al.Effect of different drying methods on chemical composition and bioactivity of tea polysaccharides[J]. International Journal Biological Macromolecules, 2013, 62: 714-719.
[74]	Zhang X, Chen H X, Zhang N, et al.Extrusion treatment for improved physicochemical and antioxidant properties of high-molecular weight polysaccharides isolated from coarse tea[J]. Food Research International, 2013, 53: 726-731.
[75]	Chen G, Yuan Q, Saeeduddin M, et al.Recent advances in tea polysaccharides: extraction, purification, physicochemical characterization and bioactivities[J]. Carbohydrate Polymers, 2016, 153: 663-678.

Research Progress of Tea Polysaccharides in Regulating Obesity

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