L-茶氨酸改善来曲唑诱导的多囊卵巢综合征大鼠临床症状

Abstract

Abstract: To explore the improvement effect of L-theanine (LTA) on the clinical symptoms of letrozole-induced polycystic ovary syndrome (PCOS) rats, twenty-eight female SD rats were randomly divided into control group, PCOS group, PCOS+low-dose LTA group, and PCOS+high-dose LTA group with 7 rats in each group. In the modeling stage, except for the control group, the other three groups were administered letrozole continuously for 28 days to induce the PCOS model. During the intervention phase, the normal control group and the PCOS group were given continuous gastric administration with normal saline, and the rats in the two LTA groups were given continuous gastric administration with the corresponding dose of LTA intervention for 30 days. The results show that compared with the PCOS group, the serum testosterone (T), luteinizing hormone (LH), insulin (INS), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), lipopolysaccharide (LPS) levels and homeostasis model assessment-insulin resistance (HOMA-IR) index in the LTA intervention group were significantly reduced (P<0.05), high-density lipoprotein cholesterol (HDL-C) was significantly increased (P<0.05), ratio of luteinizing hormone to follicle stimulating hormone (LH/FSH), fasting plasma glucose (FPG) and body weight were decreased (P>0.05). The serum estradiol (E2) of rats in the low-dose LTA intervention group was significantly increased (P<0.05). Follicle stimulating hormone (FSH) of mice in the high-dose LTA intervention group was significantly increased (P<0.05). At the same time, rat estrous cycle disorder and polycystic lesions of ovarian tissue were improved to a certain extent compared with PCOS group. The results show that LTA intervention can effectively regulate the secretion of sex hormones in PCOS rats, restore the regular changes of the estrus cycle, improve their ovarian polycystic lesions, and significantly improve insulin resistance (IR) and blood lipid metabolism disorders in PCOS rats and inhibit abnormal levels of lipopolysaccharide (LPS) secretion.

Key words: L-theanine, polycystic ovary syndrome, hyperandrogenemia, insulin resistance

CLC Number:

S571.1
R373

HUANG Qiuping, XIE Chenyang, LI Xinyu, JIN Bin, ZENG Zhen, QIAN Bo, DAI Ling, SONG Jiale. L-Theanine Ameliorated Clinical Symptoms in Letrozole-Induced Polycystic Ovary Syndrome Rats[J]. Journal of Tea Science, 2021, 41(6): 831-842.

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L-Theanine Ameliorated Clinical Symptoms in Letrozole-Induced Polycystic Ovary Syndrome Rats

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