儿茶素生物医用纳米材料研究进展

doi:10.13305/j.cnki.jts.2022.04.004

Abstract

Abstract: Catechins are a kind of bioactive substances rich in tea, which have the functions of anti-oxidation, anti-tumor, anti-virus, anti-inflammatory and immune regulation. However, due to the high activity of phenolic hydroxyl groups, catechins are easy to lose in vitro and in vivo activities, resulting in lower bioavailability. The recent development of nanobiotechnologies is expected to solve the problem of low bioavailability of catechins through ligand design, accurate synthesis and intelligent regulation, which can expand its application in the field of life and health. In this review, a summary on the progress of catechin biomedical nanomaterials in recent years, including the anti-tumor, antibacterial, anti-inflammatory, drug delivery and anti-virus activities, was firstly made. Later, the construction and biological mechanism of catechin biomedical nanomaterials were discussed in detail. Finally, future perspectives on the design and application of novel catechin nanomaterials were provided.

Key words: catechin, EGCG, nanomaterials, biomedicine, anti-tumor

CLC Number:

YU Rongxin, ZHENG Qinqin, CHEN Hongping, ZHANG Jinsong, ZHANG Xiangchun. Recent Advances in Catechin Biomedical Nanomaterials[J]. Journal of Tea Science, 2022, 42(4): 447-462.

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Recent Advances in Catechin Biomedical Nanomaterials

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[7]	CHEN Chunxiao, LOU Wenyu, DING Zhenjian, LI Zhuoye, YANG Yuanyuan, JIN Peng, DU Qizhen. Vardenafil Improves the Proliferative Inhibition of EGCG-β-lactoglobulin Nanoparticles Against Liver Cancer Cells [J]. Journal of Tea Science, 2020, 40(4): 528-535.
[8]	XU Yan, CAI Xiaqiang, XIE Qianjin, TAI Lingling, LIU Zenghui. The Intergative Effects of Epigallocatechin-3-gallate and Vitamin C on Serum Uric Acid Levels in Hyperuricemic Mice [J]. Journal of Tea Science, 2020, 40(3): 407-414.
[9]	ZHANG Jianyong, CHEN Lin, CUI Hongchun, WANG Weiwei, XUE Jinjin, XIONG Chunhua, JIANG Heyuan. Optimization of Technical Parameters for Chemical Synthesis of Theasinensin A by PBD and RSM [J]. Journal of Tea Science, 2020, 40(1): 51-62.
[10]	FANG Hongfeng, ZHANG Huixia, WANG Guohong, YANG Minhe. Fungal Mixed Fermentation for The Production of Lipase and Its Activity Analysis in Galloylated Catechin Hydrolysis [J]. Journal of Tea Science, 2019, 39(1): 88-97.
[11]	TU Zheng, MEI Huiling, LI Huan, LIU Xinqiu, Emmanuel Arkorful, ZHANG Caili, CHEN Xuan, SUN Kang, LI Xinghui. Effects of Co-fermentation by Eurotium cristatum and Lactobacillus plantarum on the Quality of Green Tea Liquid Beverage [J]. Journal of Tea Science, 2018, 38(5): 496-507.
[12]	RAN Wei, ZHANG Jin, ZHANG Xin, LIN Songbo, SUN Xiaoling. Infestation of Ectropis obliqua Affects the Catechin Metabolism in Tea Plants [J]. Journal of Tea Science, 2018, 38(2): 133-139.
[13]	ZHANG Yue, HU Yunfei, WANG Shumao, KE Zixing, LIN Jinke. Bioinformatic Analysis of MYB Transcription Factors Involved in Catechins Biosynthesis in Tea Plant (Camellia sinensis) [J]. Journal of Tea Science, 2018, 38(2): 162-173.
[14]	SUN Lili, ZENG Xiangquan, Nilesh W Gaikwad, WANG Huan, XU Hairong, YE Jianhui. Determination of Green Tea Catechin Biomarkers and It′s Relative Application [J]. Journal of Tea Science, 2017, 37(5): 429-441.
[15]	HUANG Xiangxiang, YANG Zhe, YU Lijun. Research Progress of Green Tea and EGCG for the Prevention and Mitigation of Chronic Obstructive Pulmonary Disease Caused by Cigarette Smoke [J]. Journal of Tea Science, 2017, 37(4): 332-338.