EGCG对肾缺血再灌注损伤的保护作用及其作用机制的研究

doi:10.13305/j.cnki.jts.2016.02.007

Abstract

Abstract: The study aims to investigate potential protection and mechanism of epigallocatechin gallate（EGCG） on kidney ischemia reperfusion injury. The results showed that EGCG treatment improved renal dysfuction, pathlogical change of kidney tissues, and reduced the expression of Wnt3a, β-catenin, MDA, IL-6, IFN-γ and TNF-α, but increased the levels of CAT, GP_X and SOD, suggesting that EGCG can protect the kidney from ischemia-reperfusion injury in rats which is associated with suppressing the activation of Wnt/β-catenin/p53 signaling pathway and inhibiting inflammation and oxidative stress.

Key words: EGCG, kidney ischemia reperfusion injury, inflammation, oxidative stress, Wnt/β-catenin

CLC Number:

LIU Hongguo. The Investigation of the Protection Effects and Mechanism of EGCG on Kidney Ischemia Reperfusion Injury[J]. Journal of Tea Science, 2016, 36(2): 169-174.

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The Investigation of the Protection Effects and Mechanism of EGCG on Kidney Ischemia Reperfusion Injury

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