Journal of Tea Science ›› 2019, Vol. 39 ›› Issue (2): 193-202.doi: 10.13305/j.cnki.jts.2019.02.008
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ZENG Li1,2, XIAO Wenjun1,*
Received:
2018-06-21
Published:
2019-06-13
CLC Number:
ZENG Li, XIAO Wenjun. Advances in Brain Diseases Prevention and Treatment of L- theanine[J]. Journal of Tea Science, 2019, 39(2): 193-202.
[1] 熊志奇, 徐林, 周江宁. 脑重大疾病的机理和诊治[J]. 中国科学院院刊, 2016, 31(7): 765-772. [2] Borzelleca J F, Peters D, Hall W.A 13-week dietary toxicity and toxicokinetic study with L-theanine in rats[J]. Food & Chemical Toxicology, 2006, 44(7): 1158-1166. [3] Juneja L R, Chu D C, Okubo T, et al.L-theanine—a unique amino acid of green tea and its relaxation effect in humans[J]. Trends in Food Science & Technology, 1999, 10(6/7): 199-204. [4] 刘洋, 李颂, 王春玲. 茶氨酸健康功效研究进展[J]. 食品研究与开发, 2016, 37(17): 211-214. [5] Sharma E,Joshi R,Gulati A.L-theanine: an astounding sui generis integrant in tea[J]. Food Chemistry, 2018, 242: 601-610 [6] Saeed M,Naveed M, Arif M, et al.Green tea ( [7] 陈宗懋. 茶与健康专题(七)饮茶对脑功能的改善和神经退化性疾病的预防作用[J]. 中国茶叶, 2009, 31(10): 6-7. [8] Başkan M H, Ayd?n M.Electron paramagnetic resonance studies of gamma-irradiated DL-alanine ethyl ester hydrochloride, L-theanine and L-glutamic acid dimethyl ester hydrochloride[J]. Spectrochimica Acta Part A Molecular & Biomolecular Spectroscopy, 2013, 112(8): 280-282. [9] Mu W, Zhang T, Jiang B.An overview of biological production of L-theanine[J]. Biotechnology Advances, 2015, 33(4): 335-342. [10] Scheid L, Ellinger S, Alteheld B, et al.Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea[J]. Journal of Nutrition, 2012, 142(12): 2091-2096. [11] Kitaoka S, Hayashi H, Yokogoshi H, et al.Transmural potential changes associated with the in [12] Desai M J, Gill M S, Hsu W H, et al.Pharmacokinetics of theanine enantiomers in rats[J]. Chirality, 2005, 17(3): 154-162. [13] Yamamoto S, Kimura T, Tachiki T, et al.The involvement of L-type amino acid transporters in theanine transport[J]. Bioscience Biotechnology & Biochemistry, 2014, 76(12): 2230-2235. [14] Unno T, Suzuki Y, Kakuda T, et al.Metabolism of theanine, gamma-glutamylethylamide, in rats[J]. Journal of Agricultural & Food Chemistry, 1999, 47(4): 1593-1596. [15] Yokogoshi H, Kobayashi M, Mochizuki M, et al.Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats[J]. Neurochemical Research, 1998, 23(5): 667-673. [16] Yamada T, Terashima T, Okubo T, et al.Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission[J]. Nutritional Neuroscience, 2005, 8(4): 219-226. [17] Kakuda T, Nozawa A, Sugimoto A, et al.Inhibition by theanine of binding of [3H]AMPA, [3H]Kainate, and [3H]MDL 105,519 to glutamate receptors[J]. Biosci Biotechnol Biochem, 2014, 66(12): 2683-2686. [18] 李坤成, 张开元. 功能磁共振在精神病诊断中的应用[J]. 中华医学杂志, 2008, 88(23): 1589-1591. [19] 张成. 心身疾病刚柔辨证的脑电图及脑内神经递质活性的超慢涨落图分析[D]. 北京: 中国中医科学院, 2013. [20] Nobre A C, Rao A, Owen G N. L-theanine, a natural constituent in tea,its effect on mental state [J]. Asia Pacific Journal of Clinical Nutrition, 2008, 17 1(1): 167-168. [21] Abdou A M, Higashiguchi S, Horie K, et al.Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans[J]. Biofactors, 2006, 26(3): 201-208. [22] Dodd F L, Kennedy D O, Riby L M, et al.A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood[J]. Psychopharmacology, 2015, 232(14): 2563-2576. [23] Rao T P, Ozeki M, Juneja L R.In search of a safe natural sleep aid[J]. Journal of the American College of Nutrition, 2015, 34(5): 1-12. [24] Kobayashi K, Nagato Y, Aoi N, et al.Effects of L-theanine on the release of α-brain waves in human volunteers[J]. Nippon Nogeikagaku Kaishi, 1998, 72(2): 153-157. [25] Lyon M R, Kapoor M P, Juneja L R.The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial[J]. Alternative Medicine Review, 2011, 16(4): 348-354. [26] Jang H S, Jung J Y, Jang I S, et al.L-theanine partially counteracts caffeine-induced sleep disturbances in rats[J]. Pharmacology Biochemistry & Behavior, 2012, 101(2): 217-221. [27] Ota, M, Wakabayashi, C, Sato, N, et al.Effect of L-theanine on glutamatergic function in patients with schizophrenia[J]. Acta Neuropsychiatrica, 2015, 27(5): 1-6. [28] Ritsner M S, Miodownik C, Ratner Y, et al.L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study[J]. Journal of Clinical Psychiatry, 2011, 72(1): 34-42. [29] Miodownik C, Maayan R, Ratner Y, et al.Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients[J]. Clinical Neuropharmacology, 2011, 34(4): 155-160. [30] Lu K, Gray M A, Oliver C, et al.The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans[J]. Human Psychopharmacology Clinical & Experimental, 2004, 19(7): 457-465. [31] Heese T, Jenkinson J, Love C, et al.Anxiolytic effects of L-theanine-a component of green tea-when combined with midazolam, in the male Sprague-Dawley rat[J]. Aana J, 2009, 77(6): 445-449. [32] Lee W K, Kim T I, Park S, et al.Anxiolytic effect of a combination of green tea extract and L-theanine[J]. Laboratory Animal Research, 2010, 26(1): 63-68. [33] Tian X, Sun L, Gou L, et al.Protective effect of L-theanine on chronic restraint stress-induced cognitive impairments in mice[J]. Brain Research, 2013, 1503(1): 24-32. [34] Everett J M, Gunathilake D, Dufficy L, et al.Theanine consumption, stress and anxiety in human clinical trials: A systematic review[J]. Journal of Nutrition & Intermediary Metabolism, 2016, 4: 41-42. [35] Kardashev A, Ratner Y, Ritsner M S.Add-on pregnenolone with L-theanine to antipsychotic therapy relieves negative and anxiety symptoms of schizophrenia: an 8-week, randomized, double-blind, placebo-controlled trial[J]. Clinical Schizophrenia & Related Psychoses, 2018, 12(1): 31-41. [36] Shinsuke H, Miho O, Chisato W, et al.Effects of chronic L-theanine administration in patients with major depressive disorder: an open-label study[J]. Acta Neuropsychiatrica, 2016, 29(2): 1-8. [37] 彭彬, 刘仲华, 林勇, 等. L-茶氨酸改善慢性应激大鼠抑郁行为作用研究[J]. 茶叶科学, 2014, 34(04): 355-363. [38] Cui Y, L G, Liu Y, et al. Antidepressant-like effects of L-theanine in the forced swim and tail suspension tests in mice[J]. Phytotherapy Research, 2011, 25(11): 1636-1639. [39] Wakabayashi C, Numakawa T, Ninomiya M, et al.Behavioral and molecular evidence for psychotropic effects in L-theanine[J]. Psychopharmacology, 2012, 219(4): 1099-1109. [40] Hidese S, Ota M, Wakabayashi C, et al.Effects of chronic L-theanine administration in patients with major depressive disorder: an open-label study[J]. Acta neuropsychiatrica, 2017, 29(2): 72-79. [41] Haskell C F, Kennedy D O, Milne A L, et al.The effects of L-theanine, caffeine and their combination on cognition and mood[J]. Biological Psychology, 2008, 77(2): 113-122. [42] Park S K, Jung I C, Lee W K, et al.A combination of green tea extract and L-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study[J]. Journal of Medicinal Food, 2011, 14(4): 334-343. [43] Higashiyama A, Htay H H, Ozeki M, et al.Effects of L-theanine on attention and reaction time response[J]. Journal of Functional Foods, 2011, 3(3): 171-178. [44] Dimpfel W, Kler A, Kriesl E, et al.Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin[J]. Nutritional Neuroscience, 2013, 10(3/4): 169-180. [45] Owen G N, Parnell H, De Bruin E A, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood[J]. Nutritional Neuroscience, 2013, 11(4): 193-198. [46] Kelly S P, Gomez-Ramirez M, Montesi J L, et al.L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance[J]. Journal of Nutrition, 2008, 138(8): 1572S-1577S. [47] Einöther S J, Martens V E, Rycroft J A, et al.L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness[J]. Appetite, 2010, 54(2): 406-409. [48] Kahathuduwa C N, Dassanayake T L, Amarakoon A M T, et al. Acute effects of theanine, caffeine and theanine-caffeine combination on attention[J]. Nutritional Neuroscience, 2016(2): 1-9. [49] Kahathuduwa C N, Dhanasekara C S, Chin S H, et al.l-Theanine and caffeine improve target-specific attention to visual stimuli by decreasing mind wandering: a human functional magnetic resonance imaging study[J]. Nutrition Research, 2018, 49: 67-78. [50] White D J, Klerk S D, Woods W, et al.Anti-stress, behavioural and magnetoencephalography effects of an l-theanine-based nutrient drink: a randomised, double-blind, placebo-controlled, crossover trial[J]. Nutrients, 2016, 8(1): 53-71. [51] Giles G E, Mahoney C R, Brunyé T T, et al.Caffeine and theanine exert opposite effects on attention under emotional arousal[J]. Canadian Journal of Physiology & Pharmacology, 2017, 95(1): 93-100. [52] Nathan P J, Lu K, Gray M, et al.The neuropharmacology of L-theanine ( [53] Cho H S, Kim S, Lee S Y, et al.Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death[J]. Neurotoxicology, 2008, 29(4): 656-662. [54] 吴波拉, 虞希冲, 杜冠华. L-茶氨酸减轻叠氮钠诱导的人神经母细胞瘤SH-SY5Y细胞线粒体损伤[J]. 基础医学与临床, 2013, 33(11): 1465-1469. [55] Taeil K, Yongkyung L, Sanggi P, et al.L-theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways[J]. Free Radical Biology & Medicine, 2009, 47(11): 1601-1610. [56] Mi-Ran Jo, Mi-Hee Park, Dong-Young Choi, et al.Neuroprotective effect of L-theanine on Aβ-induced neurotoxicity through anti-oxidative mechanisms in SK-N-SH and SK-N-MC cells[J]. Biomolecules & Therapeutics, 2011, 19(3): 288-295. [57] Di X, Yan J, Zhao Y, et al.L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway[J]. Neuroscience, 2010, 168(3): 778-786. [58] Kim T I, Dong Y Y, Sang G P, et al.Improvement of memory impairment by the combination of green tea extract and L-theanine through inhibition of acetylcholinesterase activity in mice[J]. Laboratory Animal Research, 2008, 24: 87-92. [59] Jamwal S, Kumar P.L-theanine, a component of green tea prevents 3-nitropropionic acid (3-NP)-induced striatal toxicity by modulating nitric oxide pathway[J]. Molecular Neurobiology, 2016, 54(3): 2327-2337. [60] Jamwal S, Singh S, Gill J S, et al.L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level[J]. European Journal of Pharmacology, 2017, 811: 171-179. [61] 王玉芬, 李春雨, 秦志祥, 等. 茶氨酸对脑缺血再灌注损伤保护作用的实验研究[J]. 中华神经医学杂志, 2006(6): 562-565. [62] 王庆利, 张力军, 吴明春, 等. 茶氨酸对脑缺血损伤大鼠自由基代谢的影响[J]. 实用医学杂志, 2008(11): 1898-1900. [63] 张燕辉, 吴明春, 王庆利. 茶氨酸对大鼠局灶性脑缺血性损伤后炎性细胞因子表达的影响[J]. 中国临床神经外科杂志, 2010, 15(9): 544-546. [64] Ceremuga T E, Martinson S, Washington J, et al.Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression[J]. The Scientific World Journal, 2014(4): 1-10. [65] Egashira N, Hayakawa K, Osajima M, et al.Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice[J]. Journal of Pharmacological Sciences, 2007, 105(2): 211-214. [66] Egashira N, Ishigami N, Pu F, et al.Theanine prevents memory impairment induced by repeated cerebral ischemia in rats[J]. Phytotherapy Research, 2008, 22(1): 65-68. [67] Zukhurova M, Prosvirnina M, Daineko A, et al.L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion[J]. Phytotherapy Research Ptr, 2013, 27(9): 1282-1287. [68] 王宁, 吕建瑞, 张珍妮, 等. 茶氨酸对全脑缺血再灌注大鼠JNK信号通路与DNA修复的影响[J]. 山西医科大学学报, 2016, 47(5): 415-418, 454. [69] 梁宇. 茶氨酸对神经干细胞增殖和分化的影响[D]. 济南: 山东大学, 2015. [70] Ben P, Zhang Z, Zhu Y, et al.L-theanine attenuates cadmium-induced neurotoxicity through the inhibition of oxidative damage and tau hyperphosphorylation[J]. Neurotoxicology, 2016, 57: 95-103. [71] Takarada T, Nakamichi N, Kakuda T, et al.Daily oral intake of theanine prevents the decline of 5-bromo-2'-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress[J]. Journal of Pharmacological Sciences, 2015, 127(3): 292-297. [72] Takarada T, Nakamichi N, Nakazato R, et al.Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells [73] Sumathi T, Asha D, Nagarajan G, et al.L-theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain[J]. Environmental Toxicology & Pharmacology, 2016, 42: 99-117. [74] Takeshima M, Miyazaki I, Murakami S, et al.L-theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes[J]. Journal of Clinical Biochemistry & Nutrition, 2016, 59(2): 93-99. [75] Schallier A, Vermoesen K, Loyens E, et al.L-theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures[J]. Nutritional Neuroscience, 2013, 16(2): 78-82. [76] 滕安国. 功能因子与免疫调控机制及功能食品开发[J]. 天津科技大学学报, 2017, 32(5): 2. |
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